I associate myself with the Prime Minister's remarks. His Government can be really proud of the national cancer plan. Cancer patients in Wokingham and across the country cannot afford for it not to be implemented or regularly updated. Will the Prime Minister leave a lasting legacy and support my private Member's Bill—the National Cancer Strategy Bill—to ensure that future Governments remain accountable for delivering the plan's targets and ambitions?

Max Hall is 14 years old. He should be worrying about school, football, friends and what he wants to be when he grows up. Instead, he is living with a high-grade brain tumour and there is no cure available to him. His parents, Jackie and Steven, want to know why children being diagnosed with brain tumours are still being told that there are no treatment options available. Why does brain tumour research remain so underfunded, when brain tumours kill more children than adults under 40 than any other cancer? Why are families like them left to search for hope themselves?

I associate the Opposition with the Prime Minister's remarks on the horrific train crash, the attacks in Edinburgh and, of course, Armed Forces Week. I want to start by congratulating the Prime Minister: he is the other party leader who won a by-election last week, although I think I am much happier with my new MP than he is with his. Two weeks ago, the Prime Minister told the House that the Government were funding defence and that everything was under control. The very next day, the Defence Secretary resigned, saying the Prime Minister was “unable” and the Treasury “unwilling” to fund the defence of our country. What changed?

I think the Prime Minister forgot to mention that we got 50% of the vote in Aberdeen South. He says that he is funding defence; the truth is he would not be in this mess if his Chancellor had found money for the defence investment plan. The Prime Minister gave her the second most important job in Britain. She was the first female Chancellor. She lives next door to him, but would not even come out to stand by him during his resignation speech; she was too busy getting ready for a selfie with the new leader. Does the Prime Minister feel let down by his Chancellor?

Labour Members are cheering so loudly, but if it is all going so fine, why is the Prime Minister resigning? The fact is the Chancellor did let him down. She is the one who snatched the winter fuel payment and who announced a disastrous Budget that killed economic growth. Because of her, a Labour Prime Minister is once again leaving office with unemployment higher than when he came in.

If it is all so fantastic, why is the Prime Minister resigning? It is very generous of him to stick by his Ministers, because they did not stick by him. He can say what he likes, but the people of Aberdeen gave their verdict—they voted Conservative against the Energy Secretary. Some Cabinet members are loyal and incompetent, as shown by a poll where 0% of teachers think that the Education Secretary is doing a good job.

The right hon. and learned Gentleman is the one who is resigning because of his MPs. The Prime Minister has been let down by an Energy Secretary who is killing industry, let down by a Chancellor who is killing jobs, and let down by Back-Benchers who do not understand that government is about tough choices. He U-turned again and again to appease them.

The right hon. and learned Gentleman is the one who is resigning because of his MPs. The Prime Minister has made many mistakes but also been let down by an Energy Secretary who is killing industry, a Chancellor who is killing jobs, and Back-Benchers who do not understand that government is about tough choices.

The Hendon constituency is proud to sit at the heart of the UK's largest Jewish community. In recent months, we have seen Jewish charities firebombed, synagogues attacked, and Jewish people stabbed in the street. Can the Government tell what they are doing not only to protect the Jewish community but also ensure they can live full and proud Jewish lives, free from fear?

I associate myself and my party with the Prime Minister's remarks about the horrifying train crash in Bedford and the appalling attacks near a mosque in Edinburgh. Our thoughts and prayers are with the victims and their families. May I mention today's review of Nottingham's maternity services, which is truly shocking? I hope that the Government will rise to the moment and implement Donna Ockenden's recommendations in full, without delay. We all know how hard it is when relationships break down with close friends and allies, and when even our next door neighbour barely speaks to us some of the time, so have the Prime Minister's experiences opened his eyes to the need to rebuild Britain's relationship with our European friends and allies? Will he advise the right hon. Member for Makerfield (Andy Burnham) to put his EU red lines in the past and to adopt our plan for a new growth and defence partnership?

As we swelter through this dangerous heatwave, we see the damage caused by extreme weather and climate change—schools closed, travel chaos, lives at risk, and massive costs to our economy and society. With the Met Office already warning that future summers will regularly break 40°C and bring even greater human and financial costs, is the Prime Minister alarmed that some parties in this House still follow Donald Trump with policies to send temperatures soaring even higher? Will the Prime Minister warn his successor not to listen to Conservative and Reform voices and instead to back our plans to cut bills and tackle climate change?

This morning, a mature street tree fell on my house. No one was hurt, but it is another reminder of the results of this extreme heat that we face. Today is the hottest June day ever on record. Extreme heat and flooding are becoming more normal, and the Government need to stay ahead of that in respect of our homes, our workplaces and our farming. As the chair of the all-party parliamentary group for the environment, I am conducting an inquiry into Government preparedness. Will the Prime Minister tell the country what actions he is taking to step up our resilience?

Diolch yn fawro, Lefarydd. The end of the Prime Minister's premiership comes close on the heels of the end of Labour's 100-year dominance in Wales. People simply did not feel that his party stood up for them, and it is irrefutable that that too is part of the Prime Minister's legacy. I believe there is a tradition of leaving notes on desks for successors. Will the Prime Minister leave a useful note to the incoming Prime Minister, saying that respect and understanding go a very long way and that democratic choices, including those of devolution, cannot be dismissed?

My constituent Jake McGregor-How, a 16-year-old with everything to live for, has been diagnosed with Friedreich's ataxia—a rare neurodegenerative condition that is cruel and swift-acting. The average life expectancy of people diagnosed with it is just 37. Despite the NHS's founding principle that care should be based on clinical need, not ability to pay, Jake's father is crowdfunding to pay for treatment in Germany with a new drug, omaveloxolone, which has received clinical approval here but is not available through the NHS. Assessment by the National Institute for Health and Care Excellence has stalled. The condition is not classed as an ultra-rare disease, yet it is rare enough that any drug to treat it will struggle to meet NICE's cost-effectiveness criteria. The family constantly have to raise enough money to pay for each round of treatment. Shockingly, Jake has recently undertaken a personal independence payment assessment and been turned down for much-needed support. Families should never have to crowdfund for treatment abroad for a life-threatening disease. Will the Prime Minister arrange for me and other colleagues who have constituents with this cruel condition to meet the Health Secretary to discuss a way forward?

I hope there is still time in which the Prime Minister will be able to enlighten his party as to the moral of the cautionary tale of Jim, who ran away from his nurse, and was eaten by a lion.

I thank the Prime Minister for his leadership. One of the concerns I hear most often from my constituents across Erdington, Kingstanding, Castle Vale and south Oscott is about the rapid growth of exempt accommodation. In my constituency and across Birmingham, properties refused house in multiple occupation licences are opening anyway as exempt accommodation, with very little scrutiny. This undermines local communities and decision makers, so will the Prime Minister confirm when new legislation will be brought forward and whether it will close the loopholes? Will that legislation and its regulations be applied retrospectively, so that communities such as mine are protected?

The first duty of His Majesty's Government, and indeed the Prime Minister's first duty, is the defence of the realm. The Prime Minister is not responsible for the worsening geopolitical situation, but he is responsible for this country's reaction to it. It is imperative that at the Ankara NATO summit early next month, we can outline to our allies how we will meet that situation. There were reports yesterday that the Prime Minister was being pushed to delay the defence investment plan again by the outriders of the new right hon. Member for Makerfield (Andy Burnham). Will he confirm to this House that he will push ahead with its publication and that it is fully funded to the level the Chief of the Defence Staff said is required—not to the level his former Defence Secretary, the right hon. Member for Rawmarsh and Conisbrough (John Healey), resigned over—and in doing so, fulfil his first duty to defend the realm?

Following last Friday's train collision south of Bedford, the emergency response from Bedfordshire police, the British Transport police, Bedfordshire fire and rescue service, the East of England ambulance service, Magpas air ambulance and other counties' air ambulances, our local NHS hospitals, and of course railway staff was swift, professional and compassionate in supporting those who were impacted, especially in such distressing circumstances. This was public service at its best. Will the Prime Minister join me in thanking all those involved for their outstanding work in the aftermath of this tragic incident?

My children, like millions of others, are kicking every ball of England's world cup campaign, but as a parent I am really concerned about their security in this country, along with other Muslim parents. Let me explain why. When a Sikh lady was raped in Walsall, the perpetrator repeatedly called her an effing Muslim bitch. There was no condemnation by a Minister at the Dispatch Box and no outcry from Members in this Chamber who openly call out these matters when the perpetrators are of a different colour. When we had the Unite the Kingdom march calling openly for the expulsion of Muslims in this country, there was no ministerial statement condemning such statements. This weekend, five members of the Muslim community were stabbed on the streets of Edinburgh. There was no ministerial statement of condemnation, no Cobra meeting and no solidarity. What does this silence say to my children as they wait with bated breath for Harry Kane to bring it home?

The hon. Member noted CISWO's accumulation of £30 million while miners' welfare, sports facilities, and community infrastructure have been neglected. He asked if the charity should face a Charity Commission inquiry and serious reform.

The hon. Member expressed satisfaction that the Met police implemented a stolen handset blacklist following advice, reducing mobile thefts by nearly half. He urged the Prime Minister to reclassify social media companies from platforms to publishers and hold them responsible for harmful content.

In Aldershot, National Armed Forces Day celebrations are returning this week. The hon. Member condemned an assault on elderly Gurkha veterans and asked if the PM would condemn it and address long-standing pension issues for Gurkhas.

The hon. Member wished Scotland well in their match and raised concerns over the refusal of a UK inquiry into the SNP's governance issues despite clear public concern.

The hon. Member participated in a Welsh Women's Aid fundraiser event 'Wuthering Heights Day' to raise awareness of violence against women and girls, asking the Prime Minister to recognise Moira Gleed's efforts.

The hon. Member asked for advice from the Prime Minister on how to succeed in office without inflicting austerity.

As you will be aware, Mr Speaker, Monday was Windrush Day, founded by Patrick Vernon to celebrate the contribution of migrants to our community. Will the Prime Minister outline exactly what this Government are doing to recognise and serve the Windrush generation, who did so much to play a vital role in our country's history?

From slashing winter fuel payments to surrendering the Chagos Islands, this Prime Minister has got every major decision wrong. It is no wonder that even his own MPs are now looking elsewhere for the answers. As this may be one of his final appearances at the Dispatch Box, will he make one final U-turn? Will he scrap Labour's disastrous grey-belt policy and help protect the precious green-belt spaces and green areas across Aldridge-Brownhills? If not, his legacy will be that he was the Prime Minister who destroyed so many of our local communities.

Gareth Southgate's documentary last month spotlighted some of the heartbreaking ways that we are failing too many young men growing up in Britain today, but it was heartening to see the inspiring work that Hitchin youth worker Dan Gaze was able to carry out with young men in my community who had found themselves in hard times. Both Dan and the boys at Hitchin boys' school who were interviewed as part of the documentary were an absolute credit to my town, but how can we make sure that we are encouraging more men into teaching and youth work roles, so that every young man growing up in Britain today can benefit from positive role models across their community?