This pandemic has shown how interconnected we are and how vulnerable we are to global challenges. When we are still grappling with covid, the climate emergency and growing hunger, why are this Government reported to be breaking their own manifesto commitment and cutting the aid budget, which saves lives and builds resilience? Will the Prime Minister stop this retreat from the global stage and take this opportunity to rule that out, here and now?

The Prime Minister will know that my constituents in Romford have to put up with a dangerous junction and flyover at Gallows Corner, which was meant to be only a temporary structure but has been there for 50 years. The Prime Minister has been there with me when he was Mayor of London. So as part of this Government's plans to build back better, will he commit today to stepping in where Sadiq Khan has failed—bankrupting Transport for London to the tune of £10 billion—and guarantee the necessary funding to replace and reshape the junction, especially as it will form a major route to and from the new lower Thames crossing?

May I start by sending my best wishes to the Prime Minister and all those across the country who are doing the right thing by following the rules and self-isolating? Devolution in Scotland, Wales and Northern Ireland is one of the proudest achievements of the last Labour Government. Until now, whatever our disagreements, there has been a very broad consensus about devolution, so why did the Prime Minister tell his MPs this week that Scottish devolution is, in his words, “a disaster”?

The single biggest threat to the future of the United Kingdom is the Prime Minister, every time he opens his mouth almost. When the Prime Minister said he wanted to take back control, nobody thought he meant from the Scottish people, but his quote is very clear. He said “devolution has been a disaster north of the border”. This is not an isolated incident. Whether it is the internal market Bill or the way the Prime Minister has sidelined the devolved Parliaments over the covid response, he is seriously undermining the fabric of the United Kingdom. Instead of talking down devolution, does he agree that we need far greater devolution of powers and resources across the United Kingdom?

Of course I do not want the break-up of the United Kingdom, but if anything is fuelling that break-up, it is the Prime Minister. Turning now to the Prime Minister's handling of the pandemic, the Prime Minister is doing the right thing by self-isolating after being notified by track and trace, but does he think he would have been able to do so if, like so many other people across the country, all he had to rely on for the next 14 days was either statutory sick pay, which is £95 a week—that is £13 a day—or a one-off payment of £500, which works out at £35 a day?

The Prime Minister must understand that there is a huge gap in the system, because if someone cannot afford to isolate, there is little point in their being tested or traced. While the Prime Minister and the Chancellor will not pay people enough to isolate properly, we learned this week that they can find £21 million of taxpayers' money to pay a go-between to deliver lucrative contracts with the Department of Health and Social Care—£21 million.

I called for a circuit breaker; the Prime Minister stood there at the Dispatch Box and said it would be a disaster and he was not going to do it. Then he caught up and did exactly that just a few weeks later. We now have a longer, harder lockdown as a result of his delay.

The Prime Minister must understand that there is a huge gap in the system, because if someone cannot afford to isolate, there is little point in their being tested or traced.

I feel like a positive rose between two negative thorns today. I am sure that my right hon. Friend is aware of recent successes that Lincoln City Football Club have enjoyed. Unfortunately, covid-19 has hit football hard, especially those clubs dependent on ticket sales. Will he urge his Cabinet colleagues to review grant funding for football clubs and perhaps outline how we can return fans to matches at all levels of the game, as I have requested in previous correspondence? As it has been a while since the Prime Minister visited Lincoln, would he care to join me at an Imps match when we can return in person as fans of the beautiful game?

May I wish the Prime Minister and all those who are self-isolating well? Over the past 20 years, Westminster has imposed an extreme Brexit, an illegal war in Iraq, £9,000 tuition fees, the Windrush scandal, the rape clause and the bedroom tax, and a decade of Tory austerity cuts which have pushed millions into poverty. At the same time, the Scottish Parliament has delivered free prescriptions, free tuition fees, free personal care, free bus travel, the baby box, the Scottish child payment, and world-leading climate action, all of which make Scotland a fairer and more equal place in which to live. Does the Prime Minister understand why the people in Scotland think it is he and his Parliament that are the real disaster?

My goodness, I am not sure if the Prime Minister was listening, because I just charted some of the achievements of the Scottish Government delivering on behalf of the people of Scotland. We have seen no apology and no regrets from this Prime Minister. His attack on devolution was not just a slip of the tongue; it was a slip of the Tory mask. The chasm between Westminster and the Scottish people has never been bigger. We now face an extreme Brexit, a power grab and another round of Tory cuts, all being imposed against our will by a Tory Government that we did not vote for. Is it not the case that the real disaster facing the people of Scotland is another 20 years of Westminster Government? Is it not clearer than ever that the only way to protect Scotland's interests, our Parliament and our place in Europe is for Scotland to become an independent country?

Tens of thousands of jobs have already been lost in aviation, and hundreds of thousands more hang in the balance. Will my right hon. Friend throw the industry a lifeline by ensuring that the Government taskforce reports in time for a testing regime to replace the current quarantine arrangements as we come out of this lockdown on 3 December?

The people of Northern Ireland will today see again the benefits of the Union, with £165 million invested in rural broadband across Northern Ireland—the result of our agreement with the Government during the last Parliament. Following on from the current population testing initiative in Liverpool, does the Prime Minister agree that Northern Ireland's 1.8 million population, which is spread across 11 local government districts, would prove ideal for the next phase of the Government's ongoing programme of work on large-scale covid testing?

I have been contacted by many constituents who are owners of leasehold flats in buildings under 18 metres in height that are covered in cladding, and the freeholder has not replaced that cladding or produced an EWS1 form. Some of these residents are desperate to move but cannot because their flats are effectively valueless without the form. Will the Prime Minister update the House on what progress is being made by the Royal Institution of Chartered Surveyors and the National Fire Chiefs Council to develop the urgently needed risk prioritisation matrix, so that my constituents can move on with their lives?

Government plans to scrap the union learning fund mean that thousands of workers—about 200,000 a year, many of them low-paid—will miss out on training opportunities. With unemployment levels rising, will the Prime Minister today act on his commitment to offer a lifetime skills guarantee to help people to train and retrain at any stage in their lives, and reverse this decision to ensure that working people can access education, training and skills for the future?

In order to truly level up constituencies like mine in Lincolnshire, we will need to mobilise billions of private capital to help us to pay for new infrastructure investment. Will the Prime Minister consider launching a new financial institution such as a national development bank to help to achieve this?

In March, the Government's chief scientific officer said that keeping covid deaths below 20,000 would be a good outcome but still an enormous number of deaths. We have now passed 50,000 deaths and suffered the deepest recession of any G7 country, with GDP dropping by 10% in the past year. Why does the Prime Minister think the UK has had the deepest recession in the G7 and the highest number of covid deaths in Europe?

Most of our fabulous independent retailers in Rugby are currently closed due to covid restrictions. While they appreciate the very welcome financial support provided by the Government, they are concerned that supermarkets and multiple retailers continue to sell the same products as them, such as homeware and clothing, enabling them to generate substantial profits while at the same time having had a holiday on the payment of business rates. Does the Prime Minister agree that there should be fairness between retailers, and that with the Government spending £200 billion to support businesses and people in these very tough times, it would be a welcome gesture from multiples who continue to trade to volunteer to pay those retailers' businesses rates?

My constituent applied for the EU settlement scheme in September 2019 for her and her son. Fifteen months on, she is still waiting for a decision on her application. With the end of the transition period just a few short weeks away, will the Prime Minister give a cast-iron guarantee that my constituent's application and all other outstanding applications to the scheme will be concluded before 31 December 2020?

It is fantastic that we will very soon have the covid vaccine, but extremely concerning that in a recent survey, one in five people say they will not take it. Does the Prime Minister agree that social media companies should be doing more to remove anti-vaccine disinformation and conspiracy theories? Will he consider including requirements to do that within the scope of the Government's forthcoming online harms Bill?

Child poverty is evil—I know; I grew up with it. The North East Child Poverty Commission reports that our region suffered the country's biggest increase in child poverty between 2015 and 2019, when half of children in Newcastle upon Tyne Central were growing up poor, and that was before covid. Yet 15,000 of the poorest households in my constituency stand to lose £1,000 a year because of planned cuts to universal credit in April. Instead of damaging last-minute U-turns, will the Prime Minister now commit to maintaining universal credit at least at the current rate?

More than 1 million fellow citizens have recovered after testing positive for covid-19. On 2 November, The BMJ reported that all those people will have protection from their T cells, which will ensure that they cannot be reinfected for at least six months. In light of that, will my right hon. Friend follow the example of Sweden and exempt from all the covid regulations those who have tested positive within the past six months and thereby show that he is following the science and also common sense?

Six out of 10 people who have died from covid-19 are disabled. Yet, during this pandemic, disabled people have seen their care cut back, have struggled to isolate without sufficient support, and have been excluded from the Government's shambolic communications. As we start Disability History Month, will the Prime Minister tell the House why disabled people have been so let down by his Government?

The Prime Minister is aware of the success we have seen across Scotland through city region and growth deals. Moray is set to benefit from both the Scottish and the UK Governments' working together on our local deal. However, will my right hon. Friend agree that the benefit to Moray could be even greater if the UK Government's contribution was spread over a shorter period than the current 15 years—say, 10 or less? Will he agree that that would be very worthwhile, beneficial and welcomed by everyone involved in the Moray growth deal?

Professor Ian Sinha from Alder Hey Children's Hospital in Liverpool, West Derby, recently stated that the environment a child develops in, even before being born, can affect its DNA detrimentally by 10%. This Government have been responsible for creating an environment that is pushing millions of families into food poverty, which will be shaping this terrifying outcome. To address this, will the Prime Minister—I ask him for the second time—work with me and other groups to put the right to food into law?

As the Prime Minister will know, the Scottish cashmere and whisky industries are being hammered by the tariffs imposed by the United States as a result of the trade dispute with the European Union. Those tariffs are now doing serious harm to such iconic Scottish products, costing us jobs in the Scottish borders. Will the Prime Minister reassure me that the Government are doing everything they possibly can to find a resolution to the dispute?

Lead researchers have suggested that structural inequalities, not genetics, are the key differential. How will the Prime Minister redress these structural inequalities as the vaccine is rolled out?